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Extract, summarize, and transform literature into action.

Pharmacovigilance - Literature Search AI

ICSR Extraction

E2B (R3) XML Compatibility

PREP Validation

Duplicate Detection

Region-based Journal Search

Literature Search AI

Transform scientific literature review with AI-powered intelligence

At Collabridge, we revolutionize literature surveillance with AI NLP and our Human + AI Review Technology (HART), automating ICSR extraction, PREP validation with Abstract highlighting and case categorization while ensuring compliance with global standards. With smart features like duplicate detection, MedDRA mapping, and advanced indexed searches across PubMed and Google Scholar, our platform delivers faster, more accurate, and consistent insights worldwide.

Multilingual support Smart Agent MedDRA mapping Auto Scheduling

Literature Search AI Advantage

Comprehensive Coverage

Access to global scientific databases and real-time literature monitoring

Smart Summarization

Automated extraction of key insights and intelligent content summarization

Email / Document Ingestion

Seamless ingestion of emails and documents (e.g., Subscribed Indices docs) for automated processing

Prompt Refinement

Refine AI prompts for more accurate, context-aware results

ICSR Case Classification & Workflow

Automated and human-verified ICSR triage, validation, and export—fully compliant and ready for integration.

Supported Case Categories

  • Valid ICSR
  • Composite ICSR
  • Safety Information
  • Non-relevant
  • Invalid

PREP Validation Flow

P
Patient
Entity extraction & validation
R
Reporter
Author/submitter check
P
Product
Drug/compound mapping
E
Event
Adverse event detection

E2B (R3) Export & Integration

  • E2B (R3) XML export readiness
  • Direct integration with Argus, ArisG
  • Automated case handoff to safety DBs

Workflow Visualization

Article Triaged
PREP Validated
E2B Exported

Literature Coverage & Ingestion

Data Sources

  • PubMed
  • Subscribed Indices
  • Google Scholar
  • Regional Journals (Gulf, EU, APAC, etc.)
  • Local language databases

Ingestion Methods

  • PDF, Word, Email, Scanned Docs (OCR)
  • Automated email/document ingestion

Multilingual Search

  • Supported Major Languages
  • Arabic, Chinese, Japanese, Russian, and more
  • Automatic language detection for abstracts and full texts
  • AI-powered translation for non-English articles
  • Handles local language journals and region-specific publications
  • Supports right-to-left scripts (Arabic, Hebrew, etc.)
  • Consistent terminology mapping across languages (e.g., MedDRA, WHO-ART)
Tip: Multilingual search ensures no critical safety information is missed, even in local or non-English journals.

Region/Country Filters

Example: Search only Gulf region journals
  • Filter by continent, country, or custom region
  • Combine region and language filters for precise results
  • Supports regulatory-specific regions (EU, APAC, MENA, etc.)
  • Ideal for local compliance and pharmacovigilance requirements
  • Quickly identify region-specific safety signals and trends
Did you know? Region/country filters help you comply with local regulations and focus on relevant literature for your markets.

Compliance & Audit Trail

Audit Trail

  • Timestamps for all actions
  • Reviewer IDs & electronic signatures
  • Version history & change log
  • Automated audit log export for compliance reviews
  • Immutable logs to prevent tampering
Why it matters: Every action is tracked and auditable, supporting regulatory inspections and internal QA.

Traceability

  • 21 CFR Part 11 electronic signature
  • Reviewer traceability & role-based access
  • Full reviewer action history for each case
  • Granular access logs for every user

Validation & SOP Package

  • URS → FRS → IQ/OQ/PQ documentation
  • Validation protocols for EMA/US FDA
  • Comprehensive SOPs for all workflows
  • Change management and version control
  • Periodic review and revalidation
Why it matters: Robust validation and SOPs ensure regulatory compliance, audit readiness, and consistent quality across all processes.

Case Study

Collabridge platform successfully completed full validation with comprehensive audit trail and reviewer traceability, demonstrating robust compliance and end-to-end Management

Human + AI Review Technology (HART)

Hybrid Review Loop

  • AI highlights abstracts and proposes case category
  • Human reviewer confirms, overrides, or adds notes
  • All actions and decisions logged for traceability
  • Supports multi-level review (QC, MR, final sign-off)
  • Reviewer feedback used to continuously improve AI accuracy
How it works: The HART loop combines AI speed with human expertise, ensuring every literature case is reviewed efficiently and compliantly.

Multi-Reviewer Workflows

  • QC and MR reviewers see AI + previous notes
  • Full reviewer chain for compliance
HART Human-AI Loop
Sample: Human + AI feedback loop with explainability

Enterprise Scalability & Integration

Scalability Metrics

  • Scales to 10M+ articles
  • 50+ concurrent reviewers
  • 99.9% uptime (SLA)

Architecture

  • Containerized microservices
  • API-first, multi-tenant, role-based access

Integrations

  • REST APIs for Argus, ArisG, Ennov
  • CRM (Veeva), cloud storage

Case Study

Used by leading global pharma:
Processes 500,000+ articles/month
99.9% uptime

Manual vs Our Solution

Challenge Manual Approach Collabridge Solution
Literature Overload Time-consuming, error-prone manual review of large volumes. AI-powered review reduces manual time by 60% with high accuracy.
Missed Insights Critical findings and safety signals can be overlooked. Comprehensive scanning ensures no critical information is missed.
Resource Heavy Requires significant time and human resources. Automated processing reduces resource needs by 85%.

Regulatory Compliance

Literature Review Standards

  • PRISMA Guidelines
  • ICH GCP Requirements

Data Security

  • GDPR Compliance
  • HIPAA Standards
  • 21 CFR Part 11
  • Data Encryption

Quality Assurance

  • ISO 9001:2015
  • GxP Guidelines
  • Quality Management
  • Validation Protocols